This expression is supposed to imply a juxtaposition of a crass or offensive action against something that is held as sacrosanct by someone else.

Coined by Ben "Yahtzee" Croshaw
"For four, what the fuck happened to Clive Winston, you pricks?! In his place we've got some multicoloured, giggly J-pop creature, and you can't play classic rock with that...thing. It's like cock-slapping the Mona Lisa."
-Ben "Yahtzee" Croshaw in his Guitar Hero III review
by Platitude May 25, 2015
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A sex act when a young "artist" tricks an old dirty art teacher into holding up a empty picture frame. He then shoots "patronage" (i.e. semen) all over her face through the frame, and earns his A.
Hey Phillip i heard you got frisky and game Mrs. C the ol' Mona Lisa Twist durring break
by SukyPirate November 17, 2009
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When a cleavage looks kind of perky and happy but also a little on the sad any unperky side at the same time.
"Have you seen Emily's breasts? Her tits are like "Wow!" but also kind of "Meh." at the same time... I feel like her cleavage is somehow smiling at me--but also frowning at me! It's like she's got that whole Mona Lisa Cleavage thing going on. You know, like auntie Sara."
by Turtleboy3000 February 12, 2016
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To mona lisa is as if one embodies a famous painting, becoming a still, quiet, person on the wall just hanging there and when you want to either scare rob or sneak up on a nigga then you being the painting actually jump off the wall and attack or do whatchu gotta do Mona.
Ok pal, you go in there and assume the possition til i get home boy in this bitch and when i say the magic word you gonna mona lisa this bitch take his money and keys then we gonna run.
by TaterJ May 30, 2021
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The artful splatter left on the back of the toilet bowl from explosive diarrhea. Almost like a fecal Rorschach test.
Man, that girl from the party last night got the green apple splatters and left a wicked mona lisa in my toilet. It's very impressive, but i wont be calling her back.
by mr.self.destruct December 13, 2022
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