Top Definition
A combination of the following words: mother, fucking, ugly, bitch.

Mo-fu-(u)gl-itch

It is obviously used as an insult.
Girl 1: Ew look at Betty today!

Girl 2: I know right? She's such a mofuglitch!

Girl 1: *snickers*
by ThundahBolt August 24, 2009
5 Words related to Mofuglitch

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