When you miss out on getting some pussy. Reasons most likely involve being too drunk, you have a girlfriend, or forgot to bring a condom and after asking girl if it was okay she refused.
Amanda:"Heyy Zach, you should come upstairs with me real quick..."
Zach:"I can't, my girlfriend is here"

Damn bro thats some missed opporpoonity
by Ralford November 16, 2010
Get the Missed Opporpoonity mug.