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1.
Adjective: 1: One who feeds primarily on methamphetamine. 2: Methamphetamine addict who is only observed lurking about during night time hours, often at an all night Wal-Mart. 3: Tweakers or methamphetamine users who live in and around the Tulsa Oklahoma metro area.

Synonymous with the words tweaker, geek, speed freak, and walker.
Did you see that gaggle of methpires huddled up outside the Kwik Mart?

Stay out of that neighborhood . . . it is a hive of methpires!
by Peter Vincent Methpire Slayer February 08, 2012