To go for several weeks on very little sleep, often becoming very depressed in the process, ala Max Payne.

May be the result of a long, strenuous project at work or school.

"Jesus Bob, you look like shit."
"Yeah, I've been Max Payne-ing it hard the last couple weeks."
by finnishhax April 2, 2009
Get the Max Payne-ing It mug.