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1.
When illiterate and/or dumb people makes a spelling mistake.

A mistake for idiots who can't spell "mistake".

The "A" and "I" keys on keyboards are so far apart that NO ONE should ever make a mistake like this.
An Urban Dictionary definition on "humans" by FlameAssassin on Feb 22, 2005: "God's biggest mastake of all."

A university professor posts on course website: Mastake in solutions to Assignment 4 corrected (Problem 37 of Chapter 4))
by VomitingStatistician December 11, 2012