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When illiterate and/or dumb people makes a spelling mistake.

A mistake for idiots who can't spell "mistake".

The "A" and "I" keys on keyboards are so far apart that NO ONE should ever make a mistake like this.
An Urban Dictionary definition on "humans" by FlameAssassin on Feb 22, 2005: "God's biggest mastake of all."

A university professor posts on course website: Mastake in solutions to Assignment 4 corrected (Problem 37 of Chapter 4))
Mastake by VomitingStatistician December 11, 2012
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masktake 

A mistake when wearing a mask. Typically associated with consuming alcohol.
Amie felt like such a fool when she caught herself sucking down her 3rd margarita when her mask was still up. She was just being Covidvgilent by pulling her mask up in between sips like she has been conditioned to do - masktake... Although she kept drinking. Drew poured her a stay-cup
masktake by the comand'r February 14, 2022

America's greatest mistake 

The 45th, in my humble opinion, will be America's greatest mistake.

French Mistake

When an otherwise straight male is persuaded to, or on a whim in the heat of the moment, engages in a homosexual act of which he later regrets and is ashamed.
Alluded to in the musical number of the same name in Mel Brooks' film "Blazing Saddles".
Having shared the intamacy of a small tent for so long, in the stress of jungle combat, Pierre and Gustav came close to making the French Mistake on many a steamy night.
French Mistake by Mo T Juste September 19, 2008

Great Mistakes 

Nickname for the Navy's Recruit Training Command (boot camp) in Great Lakes, IL. So named for the regret felt by some recruits wondering just what they got themselves into.
I can't wait to see my wife when I finish up at Great Mistakes.

I've made a huge mistake 

A phrase used often in the canceled TV show "Arrested Development". The phrase is mostly used when the characters talk to themselves after a serious of poor choices/bad events. It's used to make light of bad situations, although the characters themselves don't find it funny.
MARTA: "I was really worried about you"
GOB: "You've got nothing to worry about. We're going to be together for a long time"
MARTA: "We're family now - I'm so happy. I'm going to call the kids!"
<MARTA walks out of room>
GOB: I've made a HUGE mistake