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1.
A troublemaker, in Yiddish. Usually used by grandparents or grandparents' friends. Not exactly a compliment.
Oy, that Mashugina ate almost all my bran!
by A. Os May 01, 2006
 
2.
A jewish word for crazy person. Someone who has lost his marbles.
James threw a peach and at police officers face. He's such a mashugina.
by David Brinn July 21, 2008