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1. Mano
Short for Hermano, which means brother in Spanish.
Hey, you want a cold beer mano?
by Egyptian Magician Jun 30, 2005 add a video
2. Mano
Slang for good friend or person you have known a while and bonded with ( Mano - male ) ( mana - female ) originated from the Spanish slang of hermano (brother) someone you are close to. Popular between 2 people that originate from seperate countries. I.e Britain and Spain
Hey, Mano!

Hey!
3. mano
1. man orgasm (n.)(v.)(adj.)

manos - one man, multiple orgasms
meno - three or more men, orgasming in unison
menos - three or more men, orgasming multiple times
I mano daily with Derrick.
4. mano
Adjective - Crazy in an uber aggressive, destructive, sometimes junky, and always testosterone injected sort of way.

Originating from the first Mortal Combat game character Kano, who had a metal plate in his head he liked to head-butt opponents with.
That new Ford land destroyer is fucking mano! Damn thing comes standard with a gun rack and a 12 pack.
by tinymonkey Jun 24, 2004 add a video
5. mano
A sound effect to describe almost any situation
Person 1: and then I was like....are you listening to me?!
Person 2: mano..... (darty eyes)
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