look up any word, like the eiffel tower:
 
1.
Practical, couragous, outgoing and brillant. Smart and witty. A woman who knows what she wants, how she wants it, and how to get there. She is the true definition of leadership and pose. Mamie (2): Peace maker, creative thinker, and a intellect at heart.
Man, we are lost we need a Mamie to get us home!
by diva17 February 05, 2010
 
2.
A dim-witted, fugly virgin e-whore, often of devout Christian faith.
"You still distance-dating that girl from out west?"
"Nah dude, she was a total mamie. Couldn't stand it anymore."
by SkeezeWheezer October 10, 2011
 
3.
a young woman who goes through pms every 3 seconds
by Anonymous March 20, 2003
 
4.
derogatory name for any teacher you hate
"jeez that test was hard"
"That teachers name must be mamie"
by InternationalPH February 11, 2009