MDSB Share definition Flag Acronym - Multi Directional Splatter Botty. A syndrome that occurs with gastro intestinal illness, or a byproduct of Vindaloo comsumption. I can come into work day, I have a bad case of MDSB. MDSB by Paulsinhis30's April 6, 2009 0 0 Get merch Get the MDSB mug. Buy Now — $32.95 See more merch
