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1. Something that severely pisses you off that you lose your sense of humour.

2. Something that is so seriously unfunny that it cuts you off mid-laugh.
Dude you should not have deep fried my new ipod, it has given me a serious lolectomy.
by Zeddie June 02, 2009

Words related to Lolectomy

humourless pissed off serious unfunny