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1.
1.Meaning to lock a magazine or clip of live ammo into a weapon and then load the first round into the chamber by pulling back the charging handle and letting it fly forward, picking up the first round from the magazine on it's way.

2.Generally used to indicate "getting ready" for something big.
1.I loaded the shells into the shotgun and I pulled back the slide and said "Lock n' Load!"

2.If someone was going to approach a girl in a bar, he might say to his friends as he got up..."lock and load".
by rallala May 31, 2008
 
2.
Sex position with man on top and woman lying face down with legs together. This could also be used for anal entry.
Lock n' load is one of my favorite positions!
by jibjabber September 23, 2008