Top Definition
To predict a loss for a team during NFL which seems highly unlikely until it actually happens.

The word is derived from a man who went by the name of 'LoPresti'. He was tested for years. We've come to the conclusion that every single team he has cheered for during play-off time has lost, regardless of odds.
Damn it! That idiot just LoPresti'd my Pro-Line picks!
by Lolwut Pear January 20, 2010

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