Drunk or high as fuck; to the point that you aren't bound by the laws of nature and society and can act freely, without thinking about the consequences. Can also be used to refer to past experiences and/or events.
This term can also be similarly spelled as 'lewwwwwwssssseeeee', in order to accurately describe a particular state of being.
Man that party last night was fucking lewse, I passed out at like 3am with 2 random bitches.
Dude I just pulled like 5 cones, drank a whole carton of beer, downed a bottle of Jack Daniels. I'm so lewwwwwwssssseeeee right now!!!!!!!!!!!!!! *strips naked*