When a Lee Sin player feels an intense need to take the second part of his 'q' ability. This is usually caused by a brief decrease in brain function or overall being from the lower tiers on the League of Legends ladder.
Guy 1:Why did that Lee Sin take that 'q'?
Guy 2: It was Lee Syndrome man.
by Shenpai January 29, 2018
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Max Lee Syndrome is a Mental illness a pot user can obtain. Symptoms include minor retardation and an urge to “sesh”.
Person 1: Fat tiger baby.

Person 2: I think it’s time we get you checked for Max Lee Syndrome.
by Dr. Kevin Potty April 23, 2020
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A female's reaction to her first encounter with sexual intercourse. It is based on Peggy Lee's song "Is That All There Is?" c. 1950s.
I had the Peggy Lee Syndrome when I lost my virginity, I really wanted to know if that's all there was...
by erikamichelle October 16, 2007
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the act of one having a fat ass
Have you seen that photo of Mark Lee in the orange shorts? He's really suffering from Mark Lee Syndrome.
by DILFluver_69 March 19, 2022
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A rare and sometimes fatal disease only affecting 2 of 5 students. When students go crazy over a professor named Doctor Lee, to the extent of where they constantly have withdrawals without the presence of Doctor Lee.
Person 1: I feel empty, like something is missing.
Person 2: I really miss Dr. Lee!
Person 3: OMG is that him!?
Person 4: Y’all have serious chronic Dr. Lee Syndrome…
by Minspired August 26, 2022
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