The meaning might be more accuratly defined as an equal to as "leave me \ no way" but is basically meant as an answer to something that is not logical.
1) when someone talks to you but you have no patienece to listen for a reason.
2) when someone tells you an idea, which you try to talk him out of it.
Someone: Hey, c'mon, let's have another game!
You: Ohh... leave me in your mother...