Top Definition
A woman who is overconfident in her skills of practical problem solving. Based on the notion that she is so talented that she can do it butt naked.
Person one: "Lookout, here comes that lady who thinks she can take her car apart with a toothpick."

Person two: "Tell me about it, she's a real 'Lady MacGyver'."
by Dr.Lollypop November 14, 2013
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