Top Definition
Like LOL, ROFL and LMAO. LSHMPFO is just another abbreviation. It simply means. Laugh So Hard My Pants Fell Off.
That joke was so funny it made me LSHMPFO.
by JustAFunny. November 25, 2010
1 more definition
short for "laughing so hard my panties fell off"

used instead of lmao or lol and such
person 1: i just ate a bee

person 2: im lshmpfo!!!
by jesnoluva August 28, 2010

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