Top Definition
It's quite sad, really. LMAO, an Internet Acronym for Laughing My Ass Off, LMAO Syndrome is a were the victim; "LMAO's" so hard that there butt ox actually falls off of their body.
Poor kid, he has LMAO Syndrome.

I have LMAO Syndrome, so I take a number of pills for it everyday.
by Menogrammar February 07, 2009

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