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1.
If said in a cheerful, praising tone, it means "You're doing great, continue the good work!"

If said in a warning tone, it is a threat that means "Stop it right now, or reap the consequences!"

Praise: Wow, you've lost 35 pounds on that diet! Keep it up!

Warning: I have had all I can take of your whining! Do you want a spanking? Keep it up...!
by MistressApril September 06, 2008
175 40
 
2.
A game that involves keeping something up, with out touching it.
Oh you know Tamara, she is so good at KeepItUp.
by Mr.Pickleton April 13, 2009
12 2
 
3.
It means to keep your dick hard during sex.
My husband can't keep it up anymore.
by mister mystery October 14, 2012
26 38