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1.
An electropop singer that became popular after shane dawson used his song "trannylicious" in his videos.
Girl one: hey have you heard "Johnnyboyxo" in shane dawsons video? shes amazing

Girl two: yeah...thats a boy...
by WoahTHEREi<3BotDF June 09, 2010
 
2.
JohnnyBoyXo is an Transgender American Pop Singer/YouTube Phenomenon Who has gained over 150,000 Subscribers & Over 50 Million Viral Video Views Worldwide with her videos.
Girl: Did you ever see johnnyboyxo’s videos? Doesn’t she look like a chick?

Boy: That’s a Dude? I’d still hit it.
by YoutubeGirl444433 May 07, 2011