Top Definition
1)To fuck up beyond all repair.

2) To trainwreck something.

3) To destroy with your own stupidity
1) I ran my car into a tree and JOKO'd it.

2) She came into my blog and JOKO'd it.

3) I was so drunk I didn't know what I was saying and JOKO'd my friendship with her.
by O'CASEY November 05, 2009

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