Top Definition
The pairing of Itachi and Sakura in the manga Naruto.

Not very common in the Naruto fandom, but it holds a great potential, for it's dark and sexy and full of delicious angst !
ItaSaku shall be our ultimate OTP :<

ItaSaku is the only canon Itachi or Sakura pairing ! 8D
by RockintoMordor November 17, 2009
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