Top Definition
Alternative to the word "problem" with the same meaning.

My friends and I were at the pool one day and I overheard
them saying something, and it sounded as if one of them had a problem, and I don't know how it came out, but it did. I butt in and asked them "What's the isolem?" not knowing what I had just said, they all just busted out laughing, and then I realized what I had just said, it was just pretty bizarre and funny.

Now it's a common word among us, and we actually use it pretty often. It's great how things just happen randomly!

"Oh my god!"
"What's the isolem?!"

"Did you just..?"
"Do you have an isolem?"
by TomMac September 02, 2007

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