Top Definition
Losers. Often mistook as a misspelled "user". Isers is primarily used by those who wish to insult online users, yet not get caught by filters, since "i" is next to the "u" key.
DavidTheDivine: Alright, 'night isers.

Jkduzz: Don't you mean users?

DavidTheDivine: Yea, sure...
by Jkduzz October 25, 2007

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