no issue no tissue

Not sure how this has no definition yet and generally isn't a more common used figure of speech, because it works in multiple ways.
So, basically

1: If you don't spill anything on the floor, you're not going to have to clean it up
"Can I trust you to work alone for a bit?"
"Yeah bruh, no issues, no tissues"
2: If there's no problems, then you don't need anything to wipe the tears out of your face

"I'm fine"
"You been crying, no issues no tissues sis"
3:

A way to respond to someone inquiring requests from you that you currently don't have any
"Dude, should I get you anything from da store?"
"No issues, no tissues homeboy"

4:
When someone expects one of your experiences to have been way more intense than they really were

"Fell down de stairs"
"Ahh shit musta sucked homie"
"Nah brotha, no issues, tissues"

Look above cunt
No issue no tissue
Ya happy urban dic

by Petra Jansen November 10, 2019

Issues with Tissues

A retarded person who is uncomfortable around complicated surroundings.

"IM HAVING ISSUES WITH MY TISSUES" said the retard having issues with tissues.

by Pwa 'm' Pwa November 17, 2009

tissue issue

When you need a tissue, but don't have one on your person, which then causes an issue

I almost had a tissue issue but i had a tissue in my pocket and therefore there was no issue.

by gutter-ball j January 31, 2008

tissue issues

The perplexing conundrums that arise from leaving evidence of a recent masturbation session laying about.

Conrad: Holy crap! We've got to go back to the apartment before Pam wakes up, I forgot I left a bunch of used kleenex by the computer!
Farnsworth: Hey, your tissue issues aren't going to make me late to work, Sgt. Spank-o-tron!

by Mr. Softey February 4, 2009

Tissue Issues

When You Finger/Jerk Yourself Of To Much And Tou Use To Much Tissue To Clean It Up But Later On You Do It Again But Run Out Of Tissues

James:I Wanked Off So Hard Last Night And Ran Out Of Tissue
Rebecca:You Have Some “Tissue Issues”

by LegendaryUrban October 10, 2018

Tissue Issue

A human resource issue when someone is whining and a mock tissue to wipe the eye is necessary.

Also a human resource issue involving people rather than equipment or processes.

Are you whining? This sounds like a tissue issue.

We've got another tissue issue, the warehouse crew is bitching again.

by C. Wright May 10, 2005

Same Issue, Different Tissue

The same old shit occurring from the same old shitty people!

That slut bag WHORE banged my skinny, faggot boss. Same issue, Different Tissue!

by Jeffrey Olivo August 22, 2015