(exp.) 1. A phrase, originating in New York, used as a combination greeting, response to itself, question of welfare, response to FOGEDDABODDIT!, and response to YOU TALKIN' TA ME?.
A popular phrase coined by radio DJ and tv personality, Wendy Williams. How You Doin?! is not only a greeting of the show, but when something or someone is very gay.
A bastardization of the greeting "How are you doing?" Used by the stereotypical mobster in popular culture. Heard in countless movies, TV shows, commercials, etc. Most often used in real life by actual mobsters, Americans of Italian descent living in New York or New Jersey (and elsewhere), or retards who want to sound tough.