When you’re on a road trip and you experience diarrhea because of all the gas station food you eat.
Kevin got the highway runs on our road trip to Arizona.
by Papa Kryn June 28, 2021
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A 2 lane hallway running around a sealed clean room that is used to bypass a stairwell, that travels over said room.
Brian, wanna go to break, lets take the Scuzzle Highway.
by rameyz December 4, 2010
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A common slang term used to describe many of the prostitutes that walk along Boulder highway in Las Vegas, NV.
GUY 1: holy shit, why does that girl walking across the street look like a trainwreck?

GUY 2: Bro, that's a boulder highway Barbie......
by BHsi August 6, 2017
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