He/she/it, used when referring to someone of indeterminate gender, like an anonymous poster on a message board or a tranny.
cutegurL69: hi guys! you r right mitch most girls are bi!! i know i am! :o)
Taeger: *rolleyes* I bet you're a 56 year old retired steelworker from Allentown Pennsylvania named Bruno or something like that.
cutegurL69: *mad* fuck you teagar i am 17 years old girl from malabu ca!!
Taeger: Whatever Bruno, you can go back to jacking off now.
Mitch: :-D Aw come on T leave heshit alone.