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One answer to the question, "Is that person a whore". Meaning "ho for sure".
Frank: Is Debbie a whore?

Mike: She's a hofosho.
hofosho by Batost March 11, 2008
Related Words
Plural of hofo.

Multiple homophobic persons.
Matt: Those are the guys that called Rick a faggot.
Lisa: What a bunch of hofos!
Hofos by Rachibby June 27, 2010
A woman who likes to get completely hammered at the bar and is willing to go home with any guy!
Hey look at that chick doing shots over there, shes a hofosho!
hofosho by Berg04 January 2, 2007
A website containing pictures of girls that dress sluty but still have their clothes on.
Antonio: What the fuck r u doing?!
Drew: Chill, I'm on Hofosho. They have shirts on!
Antonio: That's it! (cold cocked on the head)
Hofosho by Dhawk July 4, 2007
girl who doesnt know how to make people laugh
"Nat, you're a hofosho and you're really not funny"
hofosho by Natalosh March 13, 2008
H.D.C.O.S. (abbr. "Heads down, cranking on stuff")

1. To be working diligently on the task(s) at hand.

2. To be working in an uninterrupted, focused manner, usually alone.
I will be working from home today, so I can be HDCOS.
HDCOS by cslingo December 4, 2017