A term for "the one that got away" or "first love" used without explaination in Hot Tub Time Machine. Only whispered, and in repetition by all friends present.
"Jenny is your Great White Buffalo. You have to break up with her tonight"
by WundrBread March 26, 2010
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Just a nice way of saying "toilet."
This phrase is most often used with the word worshiping, as in: "Neal was so repulsed by the picture that he spent the rest of the evening worshiping the Great White Buddha." This, of course, describes the act of throwing up.
by Talkmaster May 5, 2011
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An up and coming white boxer, whom white people hope will reclaim the heavyweight title. Somewhat of a mythical figure.
Tommy Morrison was the great white hope, until Lennox Lewis kicked his ass.
by Rick S March 23, 2007
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The toilet,The John,the crapper,the porcelain throne,the rest room
Dude drank too much now he's talking through the great white telephone
by subz2k2000 November 8, 2005
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When he splooges in your asshole and you fart and the cum shoots out of your ass as great white shart
Stop cumming in my ass Dad! I can't stand these great white sharts!
by cock locker February 25, 2018
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The one true love of your life. Called the Great White Buffalo because of it's rarity, elusive status.

Most people go throughout their entire lives without ever encountering a Great White Buffalo.

This is talked about in the 2010 movie "Hot Tub Time Machine"
"You're lucky you found Leslie, some people go through their whole lives and never even see their "Great White Buffalo."
by EZRJPOOWEE April 15, 2010
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Northeast Pennsylvania, specifically the Wilkes Barre/Scranton metro area. This area is known for coal mining, welfare checks, low wage jobs and poor white trash.
It took me 15 years to escape The Great White Ghetto, but I finally got out.
by Machu Pichu October 4, 2006
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