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1.
When a group consisting of four people attempt to consume 2 large pizzas, a thirty pack of beer, a 5th of hard alcohol, and an 1/8th of marijuana.
Dude! The Great American Challenge got us so fucked up last night!
by Faukin Billy Fauk October 17, 2010
 
2.
A competition of absolute manliness.
Teams of usually 3 or 4 must eat a large pizza, drink a 30 pack of beer, a 5th of hard alcohol and then complete a puzzle after all alcohol has been consumed.

A sure way to ensure that you will not remember your night.
The 6 of us died last night competing in the Great American Challenge
by Snomar March 05, 2011