Top Definition
The ultimate way of life, events, and all parts of this world and this universe. Many define part of this with their religion, or any religion can use this as just a metaphysical way to describe fate and sequence of events.

Usually used to describe something very small and unimportant and how it relates to "the big picture".
Dude to dude: "I mean really, in the grand scheme of the universe, how much is breaking up with Shannon?"
by geniusonwheels September 28, 2009
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