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1.
An interjection typically used to express deep pain or agony. Usually complemented with a demonic facial expression. Similar to phrases like, "Oh, darn it."
A: Hey, did you hear that the papaya is now extinct?

B: (prepares and executes demonic facial expression) Fuck mothers!
by Timboooooooooooooooo June 03, 2010
 
2.
someone who has exceeded the name motherfucker and has reached the next insult level
"give me back my penis you fuckmother"
by Hakko December 22, 2003