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1.
An expression of frustration.

"Edwin smacked his thumb with a hammer and then yelled 'frizzle frazzle'."

After a long hard day at work, Ed's feet were hurting so he mumbled frizzle frazzle.

by Inkazak February 07, 2009
 
2.
1. (n) Over-processed, brittle, permed hair. Apparent by split ends, and fly-aways.
Pam's bleach-blonde frizzle-frazzle rustled like dry leaves.
by Austin Smothers April 29, 2010
 
3.
1. (v) To engage in vigorous sexual activities with either yourself or another person.
Last night, while on the phone, my girlfriend asked me to frizzle frazzle.
by James x3 Bri January 20, 2006