Top Definition
a mixture of cocaine, heroin, and LSD. a variation on the classic speedball, which is simply a mixture of cocaine and heroin for intravenous injection. taken from the idea that LSD was first widely popular in the Haight-Ashbury section of San Francisco in the 1960's.
I really don't think anybody does Frisco Speedballs anymore, and that's just sad.
by mcGherk July 30, 2006
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