Fluoopies Share definition Flag Extreme diarrhea caused from the stomach flu. The combination of the flu and explosive like poo gives you the fluoopies. Wes missed work today as he had a bad case of fluoopies. Fluoopies by Weiner man January 11, 2009 0 0 Get merch Get the Fluoopies mug. Buy Now — $32.95 See more merch