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Stands for Fuck The Friend Zone, Bitches.
Used as an exclaimation of joy when someone hooks up with someone they were previously in "The Friend Zone" with
Bro #1: I nailed her last night

Bro #2: Wasn't she the friend zone girl?
Bro #1: FTFZB
FTFZB by mattboarder February 24, 2011
Related Words
FTFZ FTFZB