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1.
Kobayakawa Sena is a little guy who always gets bullied at school. Since elementary school, he always played the role of the errand boy to the extent that he has become swift and fast. Coincidentally, Hiruma Youichi and Kurita Ryukan are looking for a fast running back for their American Football team (Amefuto) and want to put Sena on the team. To hide their new star player from the eyes of other High Schools, Hiruma encases Sena in an Amefuto helmet with a dark visor and names him Eyeshield #21.
Eyeshield 21 is an anime about American football. There are a total of 145 episodes.
by Japanese Anime September 04, 2010
 
2.
1-An anime series about a young boy forced to run around a field and get tackled by bigger men.
2-A series overshadowed by a secondary character
3-American football as seen by the Japaneses and weeaboos
4-Only girls like this series, so, if a guy does, question his sexuality
Joe: LIKE OMG, I SAW EYESHIELD 21! ITS LIKE REAL AMERICAN FOOTBALL!
Matt: If you're from japan and have anime vision.
Joe: OH U!
Matt: You're gay aren't you?
by iStole October 27, 2008