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1.
A Fat girl or group of fat girls who cockblock. Slang on the word duff. Originated in NC
I was gonna smash but shawty's herd of Duffalo trampled the club
by STMONEY May 08, 2007
 
2.
a cockblocker
That Mike is one hell of a duffalo to sit on my couch while i'm trying to get a piece.
by sto8216 July 20, 2010