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1.
Taking an unusually large crap which creates a massive explosion like sound in the toilet.
We thought Hiroshima was bad until we heard Jeff drop a nuke in the bathroom.
by JayReynolds September 21, 2007
 
2.
the act of saying the n-word (nigger) it's defined this because the n-word is sometimes called the n-bomb which is a nuclear bomb. Also defined this way because the n-word is one of the most offensive words in the English language and is the language equivalent of dropping a nuclear bomb.
1.Did you hear that song new lil wayne song he drops a nuke like every 30 seconds.

2 Did Brian accidentally drop a nuke in front of the only black kid in the school?

3.Michael Richards once dropped several nukes and his career suffered because of it.
by superbear2434 July 03, 2010