mental disorder caused by an extra chromosome. causes learning difficulties as well as a flat looking face.(Kinda Like a Pug)
A great many mental patients have this disease
by Daniel Prince February 22, 2005
A tragic mental illness some kids are born with. It makes them mentally retarded and physically deformed. It is in a word something neither the parents nor the damaged child should have to go through as it places an extra heavy burden on the parents and denies the child the chance he/she deserves at life.
My son was born with down syndrome. I still love him though

Paul Gowland got his ass kicked by that kid with down syndrome. He shouldnt be picking fights with a kid like that.

The world would be a better place without down syndrome
by itsadamnshame March 22, 2010
Another name for opiate junkies who are nodding out on the shit. Often so retarded/out of it that they manage to light themselves on fire smoking heroin off of tin foil, or when they fall asleep smoking.
Dude 1: "Hey, what's wrong with that guy over there? He's sleeping and drooling all over himself, and his cigarette is so close to that pile of flammable magazines..."
Dude 2: "Oh, that's just Derek. He's got Down syndrome. Every time he gets paid he buys oxycontins."
by westernclassics October 13, 2009
Another name for your Nintendo DS is Down Syndrome.
Brian: Hey dude do you have your Down Syndrome today?
Kevin: Yea i have my Down Syndrome and i brought golden eye for multi player.
Brian: Sweet.
Kyle: What the hell is a Down Syndrome?
Brian: Jesus Christ Kyle it's a DS.
Kyle: Oh
Audie: Shut up hoe!
That stage in the night at which you've had too much to drink, partied too hard, danced too much, or drank that one spirit that really puts you on a downer. The syndrome can often be amplified if the patient is going through some sort of trauma or difficulty in his or her (sober) life. The sufferer will also attempt to start deep, meaningful conversations with friends or even unknown passers by, spilling out his or her emotions in an attempt to solve his or her problems. This is usually followed by regret the next morning.
some are more prone than others.
Robert: Hey, why's Joe slumped in his chair, not talking to anyone, on his phone (again)?
Laura: ooohh...yeah I forgot to tell you something about Joe...he's got Down Syndrome. Stay well clear of him.
by joeiles August 31, 2008
Down Sydrome is simply one of the most hilarious forms of mental defects around. If you can't laugh at Down Sydrome, you can't appreciate it.
That's the stupidest thing I ever heard, bitch must have down syndrome or something.
by Matthew D. Dillon April 18, 2008
A deformity which causes a person (or should I say an ALIEN!!!!!!) to have the face of a bulldog, have a larger forehead, a slope tongue, swollen eyes, a voice which makes them sound like martians (aliens from Mars) and it causes them to be physically and mentally retarded. EEEEEEEEEEEEEEEEEEEWWWWW!!!!
David Allanson: EEEEEEEEEEEEEWWWWWWW!!!! Down syndrome!
by wills0 July 17, 2009
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