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15. down syndrome
Another name for your Nintendo DS is Down Syndrome.
Brian: Hey dude do you have your Down Syndrome today?
Kevin: Yea i have my Down Syndrome and i brought golden eye for multi player.
Brian: Sweet.
Kyle: What the hell is a Down Syndrome?
Brian: Jesus Christ Kyle it's a DS.
Kyle: Oh
Audie: Shut up hoe!
16. Down Syndrome
That stage in the night at which you've had too much to drink, partied too hard, danced too much, or drank that one spirit that really puts you on a downer. The syndrome can often be amplified if the patient is going through some sort of trauma or difficulty in his or her (sober) life. The sufferer will also attempt to start deep, meaningful conversations with friends or even unknown passers by, spilling out his or her emotions in an attempt to solve his or her problems. This is usually followed by regret the next morning.
some are more prone than others.
Robert: Hey, why's Joe slumped in his chair, not talking to anyone, on his phone (again)?
Laura: ooohh...yeah I forgot to tell you something about Joe...he's got Down Syndrome. Stay well clear of him.
17. down syndrome
Down Sydrome is simply one of the most hilarious forms of mental defects around. If you can't laugh at Down Sydrome, you can't appreciate it.
That's the stupidest thing I ever heard, bitch must have down syndrome or something.
18. down syndrome
A term for an addiction to the band System of a Down
Mike listens to System of a Down all day, he has down syndrome.
by m-dubya May 28, 2005 add a video
19. down syndrome
A deformity which causes a person (or should I say an ALIEN!!!!!!) to have the face of a bulldog, have a larger forehead, a slope tongue, swollen eyes, a voice which makes them sound like martians (aliens from Mars) and it causes them to be physically and mentally retarded. EEEEEEEEEEEEEEEEEEEWWWWW!!!!
David Allanson: EEEEEEEEEEEEEWWWWWWW!!!! Down syndrome!
20. Down Syndrome
What you call someone who has recently been an idiot, asked an extremely stupidass question or is just a flat-out moron.
Person one: hey look at me i'm licking the floor

Person two: ... do you have fucking down syndrome?

Person one: is the Earth flat?

Person two: you have down syndrome.
21. down syndrome
an insult, to say to ones friends when they are acting 'crippled'
Clutch, are you fuckin down syndrome!
by 106_joN Mar 27, 2005 add a video
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