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1.
A particularly virulent strain of the common cold that causes one to turn into an industrial-strength douchebag
Shit, man, I think Dave caught the Douche-o-Virus.
by Dr. Cornelius June 21, 2003
 
2.
a virus gained by having a cold, or by being near sebastion.
sebastion is the cause if the douche-o-virus
by Anonymous July 16, 2003