Douche-o-virus Share definition Flag A particularly virulent strain of the common cold that causes one to turn into an industrial-strength douchebag Shit, man, I think Dave caught the Douche-o-Virus. Douche-o-virus by Dr. Cornelius June 21, 2003 0 0 Get merch Get the Douche-o-virus mug. Buy Now — $32.95 See more merch