Top Definition
/verb/ to get rid of someone or something that is annoying, like Dandruff.

/noun/ when given to someone or said in reference to being a gift it is a signal (or code) that they should disappear with no trace.
"I've Desonexed all night and she still didn't get the hint. I can't seem to get rid of her!"

"Jimmy, that guy's starting to work my last nerve. I want you you give him some Desonex for me."
by Matty P. October 20, 2006

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