The talented Ron DeSpandex has really nailed down the moves and expressions of DeSantis in a way that has caused periodic apoplectic rage to erupt from His Royal Piousness.

Ron DeSpandex by Dr Bunnygirl May 18, 2023

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Despondex

Made by Pfizer in collaboration with The Onion News Network, Despondex is the first drug designed to treat the symptoms of excessive perkiness. It can prevent loud joyful squeals when a friend calls, Christmas caroling, costume parties, talking in line at a grocery store, community potlucks, excessive hugging, and smiles.

Are you annoyingly happy?
Despondex could be right for you.
If you are in a good mood occasionally that is normal but if you have a persistant positive outlook on life you should ask your doctor about Despondex.
Now you too can waste a night sitting on the couch with your friends or family watching a TV show no one enjoys.
Despondex prevents happiness better than watching the news, considering man's impact on nature, checking your bank balance, and thinking about how old you are and how little you have accomplished.

Despondex by ericri September 10, 2009

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DeShanda

Sounds ghetto but actually she's the complete opposite! Once you meet a Deshanda you can't unmeet her. She's stunning,stubborn,indecisive,caring, fun, outgoing, goofy,and beautiful all rolled into one giant sushi roll. She's a breath of fresh air in a smoky room. Tread lightly though because once she has you in her sights your life will never be the same.

Omg look there is a Deshanda! It's Gorgeous! Bro Be careful one look from a Deshanda and you're finished with.

DeShanda by WolfpackofLions93 May 13, 2017

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Despondent

down in the dumps

Fayaz is despondent when Anthony misses their 3:30 PM hug appointment. See also: inconsolable.

Despondent by BrandonWalsh April 11, 2014

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Shuffle