When a guy gets completely rejected or denied after asking a girl out.
Guy: Babe, you're a solid 6, where I come from that's a 10
Girl: Get the hell out of here!
portmanteau of "denied" and "annihilated," indicating utter domination, humiliation and disgrace at the hands of a rival.
Jon R: Yo, the Detroit Lions just got dennihilated.
Tim R: No shit.