To take a shower and get off all the stank and funk. Originated from Anthony.
Yo I'm gonna go defunkify in the shower right quick.
by Anthony May 10, 2004
1 more definition
To get out of one's depressed, moody state.
Joe needed to defunkify after moping around for a month since his girlfriend broke up with him.
by HRH,Queenof Washington Heights July 10, 2008