To take a shower and get off all the stank and funk. Originated from Anthony.
Yo I'm gonna go defunkify in the shower right quick.
by Anthony May 10, 2004
To get out of one's depressed, moody state.
Joe needed to defunkify after moping around for a month since his girlfriend broke up with him.
by HRH,Queenof Washington Heights July 10, 2008