defo = deformed
'Defo' can be used in a variety of ways. It can be used jokingly, in moments of indignation, and even in a casual setting.
1. Ew did you see that deer? It's so defo...
2. Come on Jill, let's hang out! Don't be defo
3. I throw my hands up in the air sometimes saying A-Yo I'm a defo!
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1."defo" is a slang term used for Deforest which is a small village just north of Madison,Wisconsin. Mainly used by people from Deforest or someone else in the area in reference to Deforest.
2.an area where alcoholics and drug addicts are from
Ah, no shit man, you're from defo? What year did you graduate?

That guy is super faded, he must be from defo!

Damn Bryan you're fucked up like defo stats son!
by stuba587 April 15, 2010
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A bunch of white kids trying to be ghetto while eating donuts and doing calculus homework outside of Casey's in the either extremely frigid or unbearably muggy air, about 15 miles from Madison, WI.
Teenage DeFo resident:"DeFo fo sho!"

Non-DeFo resident: "Uh, no."
by Juliferie January 19, 2007
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A certain style of throw during the game of 'Hand Ball' where the player with the ball throws the ball so intensely strong, that it has the capability to knock several of the goalies teeth out.
kendall: did you see caitlyn throw that ball? that was totally a DeFoe Throw.
by kexybexy May 22, 2009
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A term used to describe two or more individuals in the same picture (athletes and celebrities especially) insinuating they engage in a sexual intercourse, therefore the post-coital photography is made. The term originated came from twitter or Instagram (aka ZuccPhotoAlbum)
least horny r/nbacirclejerk user: *sees a picture of Luka and salt bae* Defo smashed fr 🔥🔥🔥👿👿👿👿
by MilkLizard October 9, 2021
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Defoe Syndrome is a severe physical condition where the body starts to mutate. The legs start to get cellulite all over them. Then the upper lip amazingly gets shorter and shorter until it suddenly dissapears making closing your mouth nearly impossible.

Defoe Syndrome originates in the DeFoe Family starting with Steve and will unfortunately linger on if any female is crazy enough to have Steves Diagnosed DeFoe Syndrome babies.
"Steve what happened to your upper lip? And why are your legs so fat? Oh nevermind, he just has the DeFoe Syndrome."
by Tim Hanks June 30, 2006
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Definitely for sure!

Used when normally two or more people agree on the same topic, not to be confused with William Dafoe.
John: Want to go catch a movie?
Sadie: Sure, what are we gonna watch?
Robert: I was thinking about _______?
Sadie: Defo' fo' sho'!
by GeneralGrim October 19, 2015
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