DFW/me Share definition Flag Acronym that stands for Don't Fuck With me. DFW/me looks cool. Lollo: Hey dude what's wrong with u? Bobbo:Just, DFW/me man, I'm not in the mood. DFW/me by Kenjitheninja September 8, 2007 0 0 Get merch Get the DFW/me mug. Buy Now — $32.95 See more merch