Top Definition
a debilitating disease affecting the joints whereby one is no longer able to bend any of one's appendages. Typically, when one suffers from this disease one will waddle from side to side, foot to foot, in order to get from place to place.
Person A: Why can't she shake her booty?

Person B: Dude, she has Cupps Syndrome!

Person A: Oh...
by rooster1205 August 06, 2009
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